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Gordon Churchward
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Transmissible antibody resistance and pathogenesis of group A streptococcus; mechanisms of transposition.
Research activities in our lab is focused in three areas. First, to learn about the maintenance and dissemination of genes encoding antibiotic resistance in bacteria, we are studying the mechanism of transposition of conjugative transposons. Second, in collaboration with June R. Scott, we are investigating the DNA binding properties of the two-component regulator CovR, which regulates 15% of the genome of S. pyogenes. To explain its unusual patterns of DNA binding and cooperativity, we are studying in detail the binding of CovR to DNA, and the changes in binding due to DNA sequence and protein phosphorylation. Third, we are involved in a collaborative project to develop textiles with light activated antimicrobial activity.
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