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William Shafer
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Genetics of antibiotic resistance; antimicrobial peptides; transcriptional regulation of gene expression; mechanisms of bacterial pathogenesis.
The Shafer laboratory is interested in the Neisseria gonorrhoeae proteins that form efflux pumps to export antimicrobial compounds to the extracellular fluid and in regulation of the expression of their genes. We are also interested in defining the structure-function relationships of antibacterial peptides produced by neutrophils and certain epithelial cells. These peptides are candidates for clinical use in treating infections caused by antibiotic-resistant pathogens. Using Staphylococcus aureus as a model target pathogen for these peptides, we are isolating and studying mutants that express increased resistance
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