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Speck Bibliography

A. Research articles:

1. Speck SH, Ferguson-Miller S, Osheroff N, Margoliash E: Definition of cytochrome c binding domains by chemical modifications: Kinetics of reaction with beef mitochondrial reductase - functional organization of the respiratory chain. Proc Natl Acad Sci USA 1979;76:155-195.

2. Osheroff N, Jemmerson R, Speck SH, Ferguson-Miller S, Margoliash E: Site-specific anti-cytochrome c antibodies: Inhibition of the reactions between cytochrome c and its respiratory chain electron exchange partners. J Biol Chem 1980;254:12717-12724.

3. Hoffman BM, Roberts JE, Swanson MS, Speck SH, Margoliash E: Copper electron-nuclear double resonance of cytochrome c oxidase. Proc Natl Acad Sci USA 1980;77:1452-1456.

4. Speck SH, Osheroff N, Dethmers JK, Margoliash E, Rajagopalan KV: Definition of cytochrome c binding domains by chemical modification: Interaction of horse cytochrome c with beef sulfite oxidase and analysis of steady-state kinetics. J Biol Chem 1981;256:7394-7400.

5. Osheroff N, Speck SH, Margoliash E, Veerman ECI, Wilms J, Konig BW, Muijsers AO: The reaction of primate cytochrome c with cytochrome c oxidase. J Biol Chem 1983;258:5731-5738.

6. Veerman ECI, Wilms J, Dekker HL, Muijsers AO, van Buuren KJH, van Gelder BF, Osheroff N, Speck SH, Margoliash E: The presteady state reaction of chemically modified cytochrome c with cytochrome oxidase. J Biol Chem 1983;258:5739-5745.

7. Butler J, Chapman SK, Davies DM, Sykes AG, Speck SH, Osheroff N, Margoliash E: Preferred sites for electron transfer between cytochrome c and iron and cobalt complexes. J Biol Chem 1983;258:6400-6404.

8. Augustin MA, Chapman SK, Davies DM, Sykes AG, Speck SH, Margoliash E: Interaction of cytochrome c with the blue copper proteins, plastocyanin and azurin. J Biol Chem 1983;258:6405-6409.

9. Speck SH, Neu CA, Swanson MS, Margoliash E: Role of phospholipid in the low affinity reactions between cytochrome c and cytochrome oxidase. FEBS Lett 1983;164:379-382.

10. Speck SH, Dye D, Margoliash E: Single catalytic site model for the oxidation of ferrocytochrome c by mitochondrial cytochrome c oxidase. Proc Natl Acad Sci USA 1984;81:347-351.

11. Speck SH, Margoliash E: Characterization of the interaction of cytochrome c and mitochondrial ubiquinol-cytochrome c reductase. J Biol Chem 1984;259:1064-1072.

12. Cohen LK, Speck SH, Roberts BE, Strominger JL: Identification and mapping of polypeptides encoded by the P3HR-1 strain of Epstein-Barr virus. Proc Natl Acad Sci USA 1984;81:4183-4187.

13. Speck SH, Strominger JL: Analysis of the transcript encoding the latent Epstein-Barr Virus Nuclear Antigen 1 - A potentially polycistronic message generated by long range splicing of several exons. Proc Natl Acad Sci USA 1985;82:8305-8309.

14. Speck SH, Pfitzner A, Strominger JL: An Epstein-Barr virus transcript from a latently infected, growth-transformed B-cell line encodes a highly repetitive polypeptide. Proc Natl Acad Sci USA 1986;83:9298-9302.

15. Pfitzner AJ, Tsai EC, Strominger JL, Speck SH: Isolation and characterization of cDNA clones corresponding to transcripts from the BamHI H and F region of the Epstein-Barr virus genome. J Virol 1987;61:2902-2909.

16. Pfitzner AJ, Strominger JL, Speck SH: Characterization of a cDNA clone for a transcript from the Epstein-Barr virus BamHI M fragment: Evidence for overlapping mRNAs. J Virol 1987;61:2943-2946.

17. Quakenbush E, Clabby M, Gottesdiener KM, Barbosa J, Jones NH, Strominger JL, Speck S, Leiden JM: Molecular cloning of complementary DNAs encoding the heavy chain of the 4F2 cell-surface antigen: A Type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc Natl Acad Sci USA 1987;84:6526-6530.

18. Austin PJ, Flemington E, Yandava CN, Strominger JL, Speck SH: Complex transcription of the Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes. Proc Natl Acad Sci USA 1988;85:3678-3682.

19. Rooney C, Howe JG, Speck SH, Miller G: Influences of Burkitt lymphoma and primary B cells on latent gene expression by a non-immortalizing strain of Epstein-Barr virus J Virol 1989;63:1531-1539.

20. Woisetschlaeger M, Strominger JL, Speck SH: Mutually exclusive use of one of two viral promoters in Epstein-Barr virus latently infected lymphocytes. Proc Natl Acad Sci USA 1989;86:6498-6502.

21. Flemington E, Speck SH: Identification of phorbol ester response elements in the promoter of the Epstein-Barr virus putative lytic switch gene, BZLF1. J Virol 1990;64:1217-1226.

22. Flemington E, Speck SH: Autoregulation of the Epstein-Barr virus putative lytic switch gene, BZLF1. J Virol 1990;64:1227-1232.

23. Woisetschlaeger M, Yandava C, Strominger JL, Speck SH: Promoter switching during the initial stages of Epstein-Barr virus infection of B lymphocytes. Proc Natl Acad Sci USA 1990;87:1725-1729.

24. Rogers R, Speck SH: Epstein-Barr virus transcription from the major internal repeat (IR1) in latently infected B lymphocytes. J Virol 1990;64:2426-2429.

25. Rogers RP, Woisetschlaeger M, Speck SH: Alternative splicing dictates the translational start in Epstein-Barr virus transcripts. EMBO J 1990; 9:2273-2277.

26. Flemington E, Speck SH: Epstein-Barr virus BZLF1 trans activator induces the promoter of a cellular cognate gene, c-fos. J Virol 1990;64:4549-4552.

27. Flemington E, Speck SH. Evidence for coiled coil dimer formation by an Epstein-Barr virus transactivator that lacks a heptad repeat of leucine residues. Proc Natl Acad Sci USA. 1990;87:9459-9463.

28. Woisetschlaeger M, Jin X, Yandava C, Furmanski LA, Strominger JL, Speck SH: Role of the Epstein-Barr virus nuclear antigen 2 in viral promoter switching during initial stages of infection. Proc Natl Acad Sci USA 1991;88:3942-3946.

29. Taylor N, Flemington E, Kolman JL, Baumann RP, Speck SH, Miller G: ZEBRA and a Fos-GCN4 chimeric protein differ in their DNA-binding specificities for sites in the Epstein-Barr virus BZLF1 promoter. J Virol 1991;65:4033-4041.

30. Schaefer BC, Woisetschlaeger M, Strominger JL, Speck SH: Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt's lymphoma arises from a third promoter, distinct from the promoters utilized in latently infected lymphocytes. Proc Natl Acad Sci USA 1991;88:6550-6554.

31. Flemington E, Goldfeld AE, Speck SH: Efficient transcription of the Epstein-Barr virus BZLF1 immediate early gene post-induction with anti-Ig requires denovo protein synthesis. J Virol 1991;65:7073-7077.

32. Flemington E, Borros AM, Lytle JP, Speck SH: Characterization of the Epstein-Barr virus BZLF1 protein transactivation domain. J Virol 1992;66:922-929.

33. Jin X, Speck SH: Identification of the critical cis-elements involved in mediating EBNA 2-dependent activity of an enhancer located upstream of the Epstein-Barr virus BamHI C promoter. J Virol 1992;66:2846-2852.

34. Yandava C, Speck SH: Characterization of the deletion and rearrangement in the BamHI C region of the X50-7 Epstein-Barr virus genome, a mutant viral strain which exhibits constitutive BamHI W promoter activity. J Virol 1992;66:5646-5650.

35. Goldfeld AE, Flemington EF, Boussoitis VA, Theodos CM, Titus RG, Strominger JL, Speck SH: Transcription of the tumor necrosis gactor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. Proc Natl Acad Sci 1992;89:12198-12201.

36. Flemington E, Speck SH, Kaelin W: E2F-1 mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product. Proc Natl Acad Sci 1993;90:6914-6918.

37. Flemington E, Lytle JP, Cayrol C, Borras AM, Speck SH: DNA-binding-defective mutants of the Epstein-Barr virus lytic switch activator Zta transactivate with altered specificities. Molec Cell Biol 1994;14:3041-3052.

38. Daibata M., Speck SH, Mulder C, Sairenji T: Regulation of the BZLF1 promoter of Epstein-Barr virus by second messengers in anti-immunoglobulin treated B cells. Virology 1994;198:446-454.

39. Goldfeld AE, Flemington E, Speck SH: Cyclosporin A and FK506 block induction of the Epstein-Barr virus lytic cycle by anti-immunoglobulin. Virology 1995;209:225-229.

40. Schaefer BC, Strominger JL, Speck SH: The Epstein-Barr virus BamHI F promoter (Fp) is an early lytic promoter which is not involved in driving EBNA 1 gene transcription in group 1 Burkitt's lymphoma cell lines. J Virol 1995;69:50-39-5047.

41. Karimi L, Crawford DH, Speck S, Nicholson, LJ: Identification of an epithelial cell differentiation responsive region within the BZLF1 promoter of the Epstein-Barr virus. J Gen Virol 1995;76:759-765.

42. Schaefer BC, Strominger JL, Speck SH: Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA 1 gene promoter and transcription initiation site in group 1 Burkitt' lymphoma cell lines. Proc Natl Acad Sci USA 1995;92:10565-10569.

43. Schlager, S, Speck SH, Woisetschlager, M: Transcription of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene occurs prior to induction of the BCR2 (Cp) EBNA gene promoter during the initial stages of infection in B cells. J Virol 1996;70:3561-3570.

44. Borras AM, Strominger JL, Speck SH: Characterization of the ZI domains in the Epstein-Barr virus BZLF1 gene promoter: role in phorbol ester induction. J Virol 1996;70:3894-3901.

45. Puglielli MT, Woisetschlaeger M, Speck SH: oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalizede lymphoblastoid cell lines. J Virol 1996;70:5758-5768.

46. Weck KE, Barkon ML, Yoo LI, Speck SH, Virgin HW: Mature B cells are required for acute splenic infection but not for establishment of latency by murine gammaherpesvirus 68. J Virol 1996;70:6775-6780.

47. Schaefer BC, Strominger JL, Speck SH: A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with types I and II latency from those arising during induction of the viral lytic cycle. J Virol 1996;70:8204-8208.

48. Puglielli MT, Desai N, Speck SH: Regulation of EBNA gene transcription in lymphoblastoid cell lines: characterization of sequences downstream of BCR2 (Cp). J Virol 1997;70:120-128.

49. Schaefer BC, Strominger JL, Speck SH: Host cell-determined methylation of specific Epstein-Barr virus promoters regulates the choice between distinct viral latency programs. Mol Cell Biol 1997;17:364-377.

50. Liu S, Liu P, Borras AM, Chatila T, Speck SH: Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member. EMBO J 1997; 6:143-153.

51. Liu S, Borras AM, Liu P, Speck SH: Binding of the ubiquitous cellular transcription factors Sp1 and Sp3 to the ZI domains in the Epstein-Barr virus lytic switch BZLF1 gene promoter. Virology 1997;228:11-18.

52. Schaefer BC, Paulson E, Strominger JL, Speck SH: Constitutive activation of EBNA1 gene transcription by IRF1 and IRF2 during restricted Epstein-Barr virus latency. Mol Cell Biol 1997;17:873-886.

53. Chatila T, Ho N, Liu P, Liu S, Mosialos G, Kieff E, Speck SH: The Epstein-Barr virus-induced Ca2+/calmodulin dependent kinase type IV/Gr can trigger reactivation. J Virol 1997;71:6560-6567.

54. Virgin HW, Latreille P, Wamsley P, Weck KE, Dal Canto AJ, Speck SH: Complete Sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 1997;71:5894-5904.

55. Yoo, LI, Mooney, M, Puglielli, MT, Speck, SH: B cell lines immortalized with an EBV mutant lacking the Cp EBNA2 enhancer are biased toward utilization of the oriP-proximal EBNA gene promoter Wp1. J Virol 1997;71:9134-9142.

56. Weck, KE, Dal Canto, AJ, Gould, JD, O’Guin, Roth, KA, Saffitz, JE, Speck, SH, Virgin, HW: Murine gamma-herpesvirus 68 causes severe large vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus induced vascular disease. Nature Medicine 1997;3:1346-1353.

57. Speck, SH, Chatila, T, Flemington, E. Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene. Trends in Microbiology 1997;5:399-405.

58. Liu, P, Liu, S, Speck, SH: Identification of a negative cis element within the ZII domain of the Epstein-Barr virus lytic switch BZLF1 gene promoter. J Virol 1998;72:8230-8239.

59. Virgin, HW, Presti, RM, Li, X-Y, Liu, C, Speck, SH: Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice. J. Virol. 1999; 73:2321-2332.

60. Weck, KE, Kim, SS, Virgin, HW, Speck, SH: Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells. J. Virol. 1999; 73:3273-3283.

61. Van Berkel, V, Preiter, K, Virgin, HW, Speck , SH: Identification and initial characterization of a murine gamma-herpesvirus 68 gene encoding an abundantly secreted protein. J. Virol. 1999; 73:4524-4529.

62. Weck, KE, Kim, SS, Virgin, HW, Speck, SH: B cells regulate murine gHV68 latency. J. Virol. 1999; 73:4651-4661.

63. Van Dyk, LF, Hess, JL, Katz, JD, Jacoby, M, Speck, SH, Virgin, HW: The murine g-herpesvirus 68 v-cyclin is an oncogene that promotes cell cycle progression in primary lymphocytes. J. Virol. 1999; 73:5110-5122.

64. Kapadia, SB, Molina, H, van Burkel, V, Speck, SH, Virgin, HW: Murine g-herpesvirus 68 encodes a functional regulator of complement activation. J. Virol. 1999; 73:7658-7670.

65. Paulson, EJ, Speck, SH: Differential methylation of Epstein-Barr virus promoters facilitates viral persistence in healthy seropositive individuals. J. Virol. 1999; 73:9950-9968.

66. Clambey, ET, Virgin, HW, Speck, SH: Disruption of the murine gammaherpesvirus 68 M1 open reading frame leads to enhanced reactivation from latency. J. Virol. 2000; 73:1973-1984.

67. Liu, S, Pavlova, I, Virgin, HW, Speck, SH: Characterization of gHV68 gene 50 transcription. J. Virol. 2000; 74:2029-2037.

68. Van Burkel, V, Barrett, J, Tiffany, HL, Sechler, JMG, Murphy, PM, MeFadden, G, Speck, SH, Virgin, HW: Identification of a gamma-herpesvirus chemokine binding protein that inhibits chemokine action. J. Virol. 2000; 74:6741-6747.

69. Van Dyk, LF, Virgin, HW, Speck, SH: The murine g-herpesvirus v-cyclin is a critical regulator of reactivation from latency. J. Virol. 2000; 74:7451-7461.

70. Dal Canto, AJ, Virgin, HW, Speck, SH: Ongoing viral replication is required for gammaherpesvirus 68-induced vascular damage. J. Virol. 2000; 74:11304-11310.

71. Yoo, L, Speck, SH: Determining the role of the Epstein-Barr virus Cp EBNA2-dependent enhancer during the establishment of latency by using mutant and wild-type viruses recovered from cottontop marmoset lymphoblastoid cell lines. J. Virol. 2000; 74:11115-11120.

72. Dal Canto, AJ, Swanson, PE, Speck, SH, and Virgin HW. Immunoprivilege and mechanisms of interferon-g action in the great elastic arteries. J. Clin. Invest. 2001; 107:R15-R22.

73. Wu, TT, Tong, L, Rickabaugh, T, Speck, S, and Sun, R. Function of Rta is essential for lytic replication of murine gammaherpesvirus 68. J. Virol. 2001, 75:9262-9273.

74. Jacoby, MA, Virgin, HW, and Speck, SH: Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation. J. Virol. 2002, 76:1790-1801.

75. van Berkel, V, Levine, B, Speck, SH, and Virgin, HW: Critical role for a high affinity chemokine-binding protein in g-herpesvirus-induced meningitis. J. Clin. Invest. 2002, 109:905-914.

76. Paulson, EJ, Yates, JL, Speck, SH: Methylation of the EBV genome and establishment of restricted latency in low passage EBV infected 293 epithelial cells. Virology 2002; in press.

77. Gangappa, S, van Dyk, LF, Jewett, TJ, Speck, SH, and Virgin, HW: Identification of the in vivo role of a viral bcl-2. J. Exp. Med. 2002; 195:931-940.

78. Tibbetts, SA, van Dyk, LF, Speck, SH, and Virgin, HW: Tissue specific roles of perforin and IFNg in CD8+ T cell control of murine gamma-herpesvirus 68 latency and persistent virus replication. 2002; J. Virol., in press.

79. Moorman, NJ, Virgin, HW, and Speck, SH: Disruption of the gene encoding the gHV68 v-GPCR leads to decreased efficiency of reactivation from latency. 2002; Submitted for publication. 80. Clambey, ET, Virgin, HW, Speck, SH: Analysis of a 9.4 Kbp spontaneous deletion mutant of murine gammaherpesvirus 68. 2002; J. Virol., in press.

81. Kapadia, SB, Levine, B, Speck, SH, and Virgin, HW: Critical role of the murine gamma-herpesvirus 68 complement regulatory protein in CNS infection. 2002; Submitted for publication.

82. Van Dyk, LF, Virgin, HW, Speck, SH: The murine gammaherpesvirus 68 v-cyclin is essential for maintenance of latency in B cell-deficient mice. 2002; Manuscript in preparation.

83. Yoo, L, Wolozyniak, J, Templeton, S and Speck, SH: Deletion of enhancer sequences upstream of Wp1 is unfavorable for EBV-driven B cell immortalization. 2002; Manuscript in preparation.

84. Liu, P and Speck, SH: Characterization of Zta and Rta transactivation of the Epstein-Barr virus BRLF1 promoter. 2002; Manuscript in preparation.


B. Book chapters and Review articles (invited publications):

1. Ferguson-Miller S, Weiss H, Speck SH, Brautigan DL, Osheroff N, Margoliash E. Correlation between the kinetics and binding of cytochrome c with purified mitochondrial reductase and oxidase. In: King TE, Orri Y, Chance B, Okunuki K, eds. Cytochrome Oxidases. Amsterdam: Elsevier/North-Holland Biomedical Press, 1979:281-292.

2. Speck SH, Koppenol WH, Osheroff N, Dethmers JK, Kang CH, Margoliash E, Ferguson-Miller S. Comparison of the interaction domains on cytochrome c for mitochondrial cytochrome c oxidase, reductase, yeast cytochrome c peroxidase, and sulfite oxidase. In: Lee CP, Schatz G, Ernster L, eds. Membrane Bioenergetics. Massachusetts: Addison Wesley Publishing Co., 1980:31-43.

3. Koppenol WH, Ferguson-Miller S, Osheroff N, Speck SH, Margoliash E. The relation between the dipole moment of cytochrome c and activity with cytochrome c reductase and cytochrome c oxidase. In: King TE, Mason HS, Morrison M, eds. Oxidases and Related Redox System. New York: Pergamon Press, 1982:1037-1053.

4. Swanson M, Speck SH, Koppenol WH, Margoliash E. Cytochrome c mobility in the eukaryotic electron transport chain. In: Gibson QH, Ho C, eds. Interactions Between Iron and Proteins in Oxygen and Electron Transport. Amsterdam: Elsevier/North-Holland Press, 1982:51-56.

5. Speck SH, Strominger JL. Viral transcription and latency in Epstein-Barr virus immortalized human B-lymphocytes. In: Cohn WE, Moldave K, eds. Progress in Nucleic Acid Research and Molecular Biology. Orlando, Florida: Academic Press, 1987:189-207.

6. Speck SH, Strominger JL. Transcription of Epstein-Barr virus in latently infected, growth-transformed lymphocytes. In: Klein G, ed. Advances in Viral Oncology. New York: Raven Press, 1989:133-150.

7. Speck SH, Strominger JL. Transformation of human cells by Epstein-Barr virus. In: Frei E, ed. The Regulation of Proliferation and Differentiation in Normal and Neoplastic Cells. Orlando, Florida: Academic Press, 1989:105-113.

8. Speck SH. Epstein-Barr virus transcription in latently infected B lymphocytes. In: Fan HY, ed. Viruses That Affect the Immune System. Washington, DC: American Society for Microbiology, 1991:219-229.

9. Rogers R, Strominger JL, Speck SH. Epstein-Barr virus in B lymphocytes: viral gene expression and function in latency. In: Vande Woude GF, Klein G, eds. Advances in Cancer Research. Orlando Florida: Academic Press, 1991:1-29.

10. Speck SH, Woisetschlaeger M, Schaefer B, Jin X, Yandava N. Transcription of the EBV genome in latently infected lymphocytes. In: Tursz, T, Pagano, J, Alblashi, DV, de The, G, Lenoir, G, Pearson, GR, eds. The Epstein-Barr Virus and Associated Diseases. John Libbey Eurotext Ltd., 1993:105-114.

11. Woisetschlaeger M, Speck SH. Epstein-Barr virus. In: McKendall RR, Stroop WG, eds. Handbook of Neurovirology. New York: Marcel Dekker Inc., 1994:289-296.

12. Speck, SH, Virgin, HW: Host and viral genetics of chronic infection: a mouse model of gamma-herpesvirus pathogenesis. Current Opinion in Microbiology 1999; 2:403-409.

13. Virgin, HW, Speck, SH: Unraveling immunity to gamma-herpesviruses: a new model for understanding the role of immunity to chronic virus infection. Current Opinion in Immunology 1999; 11:371-379.

14. Yoo, L.I, Speck, SH: Regulation of EBNA gene expression. EBV Report 2000; 7:
175-185.